GABRR2

Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene.^[5][6]

GABRR2
Identifiers
Aliases	GABRR2, gamma-aminobutyric acid type A receptor rho2 subunit, gamma-aminobutyric acid type A receptor subunit rho2
External IDs	OMIM: 137162; MGI: 95626; HomoloGene: 20471; GeneCards: GABRR2; OMA:GABRR2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,254,464 bp[1] End 89,315,299 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 14.64 cM Start 33,062,999 bp[2] End 33,095,865 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava gonad germ cell male germ cell skeletal muscle tissue deltoid muscle sperm tibialis anterior muscle spleen smooth muscle tissue Top expressed in neural layer of retina embryo embryo muscle of thigh blood right kidney superior colliculus epithelium of lens cerebellar cortex medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity protein domain specific binding transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane GABA-A receptor complex postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane chloride channel complex cell junction neuron projection GABA-ergic synapse Biological process gamma-aminobutyric acid signaling pathway chloride transmembrane transport ion transport chloride transport signal transduction visual perception chemical synaptic transmission ion transmembrane transport regulation of membrane potential nervous system process regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2570 14409 Ensembl ENSG00000111886 ENSMUSG00000023267 UniProt P28476 P56476 RefSeq (mRNA) NM_002043 NM_008076 RefSeq (protein) NP_002034 NP_032102 Location (UCSC) Chr 6: 89.25 – 89.32 Mb Chr 4: 33.06 – 33.1 Mb PubMed search [3] [4]
Wikidata
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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR2 is a member of the rho subunit family.^[6]

See also

• GABA_A-ρ receptor