GAL3ST2

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.^[5][6]

GAL3ST2
Identifiers
Aliases	GAL3ST2, GAL3ST-2, GP3ST, galactose-3-O-sulfotransferase 2
External IDs	OMIM: 608237; MGI: 2685834; HomoloGene: 41471; GeneCards: GAL3ST2; OMA:GAL3ST2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 241,776,822 bp[1] End 241,804,287 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 93,789,028 bp[2] End 93,804,216 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa mucosa of transverse colon rectum epithelium of colon stromal cell of endometrium right uterine tube superior frontal gyrus right lobe of liver appendix gallbladder Top expressed in jejunum ileum colon duodenum morula embryo blastocyst zygote spleen thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity galactosylceramide sulfotransferase activity protein binding Cellular component integral component of membrane Golgi cisterna membrane Golgi apparatus membrane Biological process glycolipid biosynthetic process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64090 381334 Ensembl ENSG00000154252 ENSG00000276126 ENSMUSG00000094651 UniProt Q9H3Q3 Q6XQH0 RefSeq (mRNA) NM_022134 NM_199366 RefSeq (protein) NP_071417 NP_001192178 Location (UCSC) Chr 2: 241.78 – 241.8 Mb Chr 1: 93.79 – 93.8 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2.^[6]