GAL3ST3

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.^[5][6][7]

GAL3ST3
Identifiers
Aliases	GAL3ST3, GAL3ST-3, GAL3ST2, galactose-3-O-sulfotransferase 3
External IDs	OMIM: 608234; MGI: 3617843; HomoloGene: 57198; GeneCards: GAL3ST3; OMA:GAL3ST3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 66,040,765 bp[1] End 66,049,161 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,348,359 bp[2] End 5,358,766 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad left lobe of thyroid gland right lobe of thyroid gland caudate nucleus putamen right auricle of heart nucleus accumbens right hemisphere of cerebellum right frontal lobe prefrontal cortex Top expressed in hippocampus proper primary visual cortex striatum of neuraxis superior frontal gyrus dentate gyrus of hippocampal formation granule cell cerebellum cerebellar cortex neural tube mesencephalon olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function galactose 3-O-sulfotransferase activity transferase activity galactosylceramide sulfotransferase activity proteoglycan sulfotransferase activity 3'-phosphoadenosine 5'-phosphosulfate binding carbohydrate binding Cellular component integral component of membrane Golgi cisterna membrane Golgi apparatus membrane Biological process glycolipid biosynthetic process sulfur compound metabolic process poly-N-acetyllactosamine metabolic process oligosaccharide metabolic process proteoglycan biosynthetic process monosaccharide metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89792 545276 Ensembl ENSG00000175229 ENSMUSG00000047658 UniProt Q96A11 P61315 RefSeq (mRNA) NM_033036 NM_001024717 RefSeq (protein) NP_149025 NP_001019888 Location (UCSC) Chr 11: 66.04 – 66.05 Mb Chr 19: 5.35 – 5.36 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3.^[7]