GALNT14

Polypeptide N-acetylgalactosaminyltransferase 14 is an enzyme that in humans is encoded by the GALNT14 gene.^[4][5]

GALNT14
Identifiers
Aliases	GALNT14, GALNT15, GalNac-T10, GalNac-T14, polypeptide N-acetylgalactosaminyltransferase 14
External IDs	OMIM: 608225; MGI: 1918935; HomoloGene: 56997; GeneCards: GALNT14; OMA:GALNT14 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.1 Start 30,910,467 bp[1] End 31,155,202 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule renal medulla human kidney nasal epithelium glomerulus lateral nuclear group of thalamus metanephric glomerulus endothelial cell epithelium of esophagus periodontal fiber n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity metal ion binding carbohydrate binding polypeptide N-acetylgalactosaminyltransferase activity Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Biological process protein glycosylation O-glycan processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79623 71685 Ensembl ENSG00000158089 n/a UniProt Q96FL9 Q8BVG5 RefSeq (mRNA) NM_001253826 NM_001253827 NM_024572 NM_001329095 NM_001329096 NM_001329097 NM_027864 RefSeq (protein) NP_001240755 NP_001240756 NP_001316024 NP_001316025 NP_001316026 NP_078848 NP_082140 Location (UCSC) Chr 2: 30.91 – 31.16 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

GALNT14 (EC 2.4.1.41) belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the first step in the O-glycosylation of mammalian proteins by transferring N-acetyl-D-galactosamine (GalNAc) to peptide substrates.[supplied by OMIM]^[5]

SNPs on GALNT14 have been shown to be associated to the chemotherapy responses of patients with advanced hepatocellular carcinoma.^[6][7][8][9]