GALNT2

Polypeptide N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the GALNT2 gene.^[5][6][7]

GALNT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FFU, 2FFV, 4D0T, 4D0Z, 4D11, 5AJN, 5AJO, 5AJP, 5FV9
Identifiers
Aliases	GALNT2, GalNAc-T2, polypeptide N-acetylgalactosaminyltransferase 2, CDG2T
External IDs	OMIM: 602274; MGI: 894694; HomoloGene: 3297; GeneCards: GALNT2; OMA:GALNT2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 230,057,990 bp[1] End 230,282,122 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E2 Start 124,958,130 bp[2] End 125,072,463 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta cartilage tissue gastric mucosa right coronary artery stromal cell of endometrium body of pancreas palpebral conjunctiva right lobe of liver left coronary artery Top expressed in lens yolk sac pancreas stomach islet of Langerhans proximal tubule neural tube mesencephalon skeletal muscle tissue right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity manganese ion binding glycosyltransferase activity metal ion binding protein binding carbohydrate binding polypeptide N-acetylgalactosaminyltransferase activity Cellular component integral component of membrane integral component of Golgi membrane Golgi apparatus membrane Golgi membrane extracellular region Golgi cisterna membrane perinuclear region of cytoplasm Golgi stack extracellular exosome endoplasmic reticulum membrane Biological process protein O-linked glycosylation via serine protein glycosylation protein O-linked glycosylation via threonine O-glycan processing protein O-linked glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2590 108148 Ensembl ENSG00000143641 ENSMUSG00000089704 UniProt Q10471 Q6PB93 RefSeq (mRNA) NM_001291866 NM_004481 NM_139272 RefSeq (protein) NP_001278795 NP_004472 NP_644678 Location (UCSC) Chr 1: 230.06 – 230.28 Mb Chr 8: 124.96 – 125.07 Mb PubMed search [3] [4]
Wikidata
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This gene encodes polypeptide N-acetylgalactosaminyltransferase 2, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. The localization site of this particular enzyme is preponderantly the trans-Golgi.^[8] Individual GalNAc-transferases have distinct activities, and initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases.^[7]