GANC

Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene.^[5][6][7]

GANC
Identifiers
Aliases	GANC, glucosidase alpha, neutral C
External IDs	OMIM: 104180; MGI: 1923301; HomoloGene: 25627; GeneCards: GANC; OMA:GANC - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 42,273,233 bp[1] End 42,356,935 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 120,234,377 bp[2] End 120,292,181 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve monocyte right lung bone marrow cells Achilles tendon rectum upper lobe of left lung right coronary artery Descending thoracic aorta muscle of thigh Top expressed in zygote muscle of thigh spermatocyte secondary oocyte right kidney neural layer of retina granulocyte genital tubercle spermatid brown adipose tissue More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 2595 76051 Ensembl ENSG00000214013 ENSMUSG00000062646 UniProt Q8TET4 Q8BVW0 RefSeq (mRNA) NM_198141 NM_001301409 NM_001301410 NM_172672 RefSeq (protein) NP_001288338 NP_001288339 NP_937784 NP_766260 Location (UCSC) Chr 15: 42.27 – 42.36 Mb Chr 2: 120.23 – 120.29 Mb PubMed search [3] [4]
Wikidata
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Function

Glycoside hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes.^[7]