GAPDHS

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic or glyceraldehyde-3-phosphate dehydrogenase, testis-specific is an enzyme that in humans is encoded by the GAPDHS gene.^[5][6]

GAPDHS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H9E, 3PFW, 5C7O, 5C7L
Identifiers
Aliases	GAPDHS, GAPD2, GAPDH-2, GAPDS, HSD-35, HEL-S-278, glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
External IDs	OMIM: 609169; MGI: 95653; HomoloGene: 101265; GeneCards: GAPDHS; OMA:GAPDHS - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,533,455 bp[1] End 35,545,319 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 30,429,200 bp[2] End 30,443,106 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle skin of leg skin of abdomen granulocyte right uterine tube tail of epididymis metanephros Top expressed in seminiferous tubule spermatid spermatocyte gastrula embryo tail of embryo neural layer of retina blastocyst tibiofemoral joint muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity NAD binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor protein binding NADP binding glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Cellular component cytoplasm cytosol nucleus Biological process flagellated sperm motility gluconeogenesis glycolytic process positive regulation of glycolytic process canonical glycolysis glucose metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26330 14447 Ensembl ENSG00000105679 ENSMUSG00000061099 UniProt O14556 Q64467 RefSeq (mRNA) NM_014364 NM_001290631 NM_008085 RefSeq (protein) NP_055179 NP_001277560 NP_032111 Location (UCSC) Chr 19: 35.53 – 35.55 Mb Chr 7: 30.43 – 30.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.^[6]

In melanocytic cells GAPDHS gene expression may be regulated by MITF.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

1. The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".