GAS2

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.^[5][6]

GAS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V5R
Identifiers
Aliases	GAS2, growth arrest specific 2, GAS-2
External IDs	OMIM: 602835; MGI: 95657; HomoloGene: 31301; GeneCards: GAS2; OMA:GAS2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p14.3 Start 22,625,509 bp[1] End 22,813,001 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B4|7 32.87 cM Start 51,511,763 bp[2] End 51,644,723 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion liver sural nerve right lobe of liver islet of Langerhans C1 segment Skeletal muscle tissue of rectus abdominis Achilles tendon gonad spinal ganglia Top expressed in vestibular sensory epithelium stria vascularis vestibular membrane of cochlear duct right kidney proximal tubule utricle human kidney hand cochlea saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding actin binding Cellular component cytoskeleton cytosol actin filament membrane cytoplasm Biological process cell cycle regulation of cell shape apoptotic process initiation of primordial ovarian follicle growth antral ovarian follicle growth regulation of Notch signaling pathway ovulation basement membrane organization microtubule cytoskeleton organization actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2620 14453 Ensembl ENSG00000148935 ENSMUSG00000030498 UniProt O43903 P11862 RefSeq (mRNA) NM_001143830 NM_005256 NM_177553 NM_001351224 NM_001391933 NM_001391934 NM_001391935 NM_001391936 NM_001391937 NM_008087 NM_001330607 NM_001330608 RefSeq (protein) NP_001137302 NP_005247 NP_808221 NP_001338153 NP_001317536 NP_001317537 NP_032113 Location (UCSC) Chr 11: 22.63 – 22.81 Mb Chr 7: 51.51 – 51.64 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[6]