GCHFR

GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.^[5][6][7]

GCHFR
Identifiers
Aliases	GCHFR, GFRP, HsT16933, P35, GTP cyclohydrolase I feedback regulator
External IDs	OMIM: 602437; MGI: 2443977; HomoloGene: 3849; GeneCards: GCHFR; OMA:GCHFR - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 40,764,068 bp[1] End 40,767,708 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 118,998,254 bp[2] End 119,002,871 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver olfactory zone of nasal mucosa mucosa of transverse colon right lung jejunal mucosa mucosa of ileum duodenum human kidney upper lobe of left lung oral cavity Top expressed in right kidney left lobe of liver proximal tubule olfactory epithelium jejunum interventricular septum embryo blood lobe of prostate human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP cyclohydrolase binding enzyme inhibitor activity amino acid binding protein binding enzyme binding GTP-dependent protein binding Cellular component cytoplasm cytosol nuclear membrane membrane melanosome dendrite nucleus nucleoplasm protein-containing complex Biological process nitric oxide biosynthetic process protein heterooligomerization negative regulation of GTP cyclohydrolase I activity neurotransmitter metabolic process negative regulation of biosynthetic process protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2644 320415 Ensembl ENSG00000137880 ENSMUSG00000046814 UniProt P30047 P99025 RefSeq (mRNA) NM_005258 NM_177157 RefSeq (protein) NP_005249 NP_796131 Location (UCSC) Chr 15: 40.76 – 40.77 Mb Chr 2: 119 – 119 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.^[7]