GCLM

For the post-nomial, see Legion of Merit (Rhodesia).

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.^[5][6]

GCLM
Identifiers
Aliases	GCLM, GLCLR, glutamate-cysteine ligase modifier subunit
External IDs	OMIM: 601176; MGI: 104995; HomoloGene: 1557; GeneCards: GCLM; OMA:GCLM - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.1 Start 93,885,199 bp[1] End 93,909,456 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G1|3 52.94 cM Start 122,039,206 bp[2] End 122,064,381 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell islet of Langerhans jejunal mucosa hair follicle secondary oocyte cartilage tissue Skeletal muscle tissue of rectus abdominis epithelium of nasopharynx duodenum trabecular bone Top expressed in right kidney stroma of bone marrow blood fetal liver hematopoietic progenitor cell left lobe of liver human kidney tibiofemoral joint pyloric antrum lacrimal gland facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme regulator activity glutamate-cysteine ligase catalytic subunit binding protein heterodimerization activity glutamate-cysteine ligase activity Cellular component cytosol glutamate-cysteine ligase complex Biological process negative regulation of neuron apoptotic process glutathione metabolic process cysteine metabolic process negative regulation of extrinsic apoptotic signaling pathway regulation of mitochondrial depolarization apoptotic mitochondrial changes response to nitrosative stress glutamate metabolic process glutathione biosynthetic process positive regulation of glutamate-cysteine ligase activity response to oxidative stress ageing cellular response to thyroxine stimulus hepatic stellate cell activation cellular response to follicle-stimulating hormone stimulus cellular response to fibroblast growth factor stimulus response to human chorionic gonadotropin response to nutrient response to activity cellular response to hepatocyte growth factor stimulus cellular response to glucose stimulus cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2730 14630 Ensembl ENSG00000023909 ENSMUSG00000028124 UniProt P48507 O09172 RefSeq (mRNA) NM_001308253 NM_002061 NM_008129 RefSeq (protein) NP_001295182 NP_002052 NP_032155 Location (UCSC) Chr 1: 93.89 – 93.91 Mb Chr 3: 122.04 – 122.06 Mb PubMed search [3] [4]
Wikidata
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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia.^[6]