KAT2A

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.^[5][6]

KAT2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F68, 1Z4R, 3D7C, 5H86, 5H84
Identifiers
Aliases	KAT2A, GCN5, GCN5L2, PCAF-b, hGCN5, lysine acetyltransferase 2A
External IDs	OMIM: 602301; MGI: 1343101; HomoloGene: 41343; GeneCards: KAT2A; OMA:KAT2A - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,113,111 bp[1] End 42,121,367 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.53 cM Start 100,595,572 bp[2] End 100,603,291 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left ovary right ovary right hemisphere of cerebellum right adrenal cortex right frontal lobe left uterine tube left adrenal cortex body of uterus canal of the cervix Top expressed in internal carotid artery external carotid artery otic placode tail of embryo otic vesicle saccule genital tubercle epiblast lacrimal gland hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity transcription coactivator activity N-acetyltransferase activity transcription factor binding histone deacetylase binding chromatin binding H3 histone acetyltransferase activity protein binding acetyltransferase activity histone acetyltransferase activity (H4-K12 specific) protein phosphatase binding acyltransferase activity histone acetyltransferase activity thiol-dependent deubiquitinase peptide-lysine-N-acetyltransferase activity histone succinyltransferase activity Cellular component transcription factor TFTC complex nucleoplasm histone acetyltransferase complex mitotic spindle extracellular space nucleus chromosome cytoplasm centrosome microtubule organizing center cytoskeleton oxoglutarate dehydrogenase complex Biological process positive regulation of transcription regulatory region DNA binding somitogenesis epigenetic maintenance of chromatin in transcription-competent conformation chromatin remodeling metencephalon development cellular response to nerve growth factor stimulus regulation of transcription, DNA-templated regulation of protein stability response to organic cyclic compound multicellular organism growth positive regulation of protein targeting to mitochondrion regulation of transcription by RNA polymerase II cardiac muscle cell differentiation cellular response to tumor necrosis factor histone H3-K14 acetylation positive regulation of cell projection organization in utero embryonic development transcription by RNA polymerase II transcription, DNA-templated nervous system development positive regulation of histone acetylation histone deubiquitination telencephalon development neural tube closure response to nutrient levels regulation of autophagy of mitochondrion histone acetylation histone H3 acetylation cell population proliferation viral process intracellular distribution of mitochondria histone H4-K12 acetylation alpha-tubulin acetylation midbrain development protein deubiquitination cytokine production heart development long-term memory internal peptidyl-lysine acetylation regulation of regulatory T cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of centriole replication regulation of synaptic plasticity regulation of T cell activation limb development histone succinylation positive regulation of cardiac muscle cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2648 14534 Ensembl ENSG00000108773 ENSMUSG00000020918 UniProt Q92830 Q9JHD2 RefSeq (mRNA) NM_021078 NM_001376227 NM_001038010 NM_020004 RefSeq (protein) NP_066564 NP_001363156 NP_001033099 NP_064388 Location (UCSC) Chr 17: 42.11 – 42.12 Mb Chr 11: 100.6 – 100.6 Mb PubMed search [3] [4]
Wikidata
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Interactions

GCN5L2 has been shown to interact with:

• DDB1,^[7]
• Ku70,^[8]
• Ku80,^[8]
• TADA2L,^[8][9]
• TAF9,^[7] and
• Transcription initiation protein SPT3 homolog.^[7][10]