TADA2L

Transcriptional adapter 2-alpha is a protein that in humans is encoded by the TADA2A gene.^[5][6]

TADA2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X41
Identifiers
Aliases	TADA2A, ADA2, ADA2A, TADA2L, hADA2, KL04P, transcriptional adaptor 2A
External IDs	OMIM: 602276; MGI: 2144471; HomoloGene: 38834; GeneCards: TADA2A; OMA:TADA2A - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 37,406,886 bp[1] End 37,479,725 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 83,969,746 bp[2] End 84,020,426 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Achilles tendon corpus callosum ventricular zone ganglionic eminence right testis left testis bone marrow cell skeletal muscle tissue endometrium Top expressed in otic vesicle saccule neural layer of retina epiblast renal corpuscle ventricular zone otic placode secondary oocyte primary oocyte medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding histone acetyltransferase activity DNA-binding transcription factor activity DNA binding chromatin binding transcription coregulator activity transcription coactivator activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus chromosome SAGA-type complex Biological process positive regulation of histone acetylation histone H3 acetylation regulation of transcription, DNA-templated transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription, DNA-templated chromatin remodeling regulation of histone acetylation positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6871 217031 Ensembl ENSG00000276234 ENSG00000277104 ENSMUSG00000018651 UniProt O75478 Q8CHV6 RefSeq (mRNA) NM_001166105 NM_001291918 NM_001488 NM_133439 NM_172562 RefSeq (protein) NP_001159577 NP_001278847 NP_001479 NP_597683 NP_766150 Location (UCSC) Chr 17: 37.41 – 37.48 Mb Chr 11: 83.97 – 84.02 Mb PubMed search [3] [4]
Wikidata
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Function

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.^[6]

Interactions

TADA2L has been shown to interact with GCN5L2,^[7][8] TADA3L^[9][10] and Myc.^[11]