GDF7

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.^[5]

GDF7
Identifiers
Aliases	GDF7, BMP12, growth differentiation factor 7
External IDs	OMIM: 604651; MGI: 95690; HomoloGene: 32177; GeneCards: GDF7; OMA:GDF7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.1 Start 20,667,144 bp[1] End 20,679,243 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 8,347,918 bp[2] End 8,351,954 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula endometrium Descending thoracic aorta ascending aorta mucosa of paranasal sinus ectocervix right coronary artery canal of the cervix kidney tubule popliteal artery Top expressed in uterus embryo finger foot shoulder toe rhombencephalon cerebellar cortex striatum of neuraxis primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity protein homodimerization activity protein binding transforming growth factor beta receptor binding growth factor activity Cellular component extracellular region extracellular space Biological process regulation of apoptotic process pathway-restricted SMAD protein phosphorylation cell fate commitment epithelial cell differentiation regulation of MAPK cascade SMAD protein signal transduction spinal cord association neuron differentiation cell development positive regulation of tendon cell differentiation positive regulation of pathway-restricted SMAD protein phosphorylation roof plate formation BMP signaling pathway axon guidance reproductive structure development positive regulation of transcription, DNA-templated forebrain morphogenesis gland morphogenesis positive regulation of gene expression positive regulation of neuron differentiation neural tube development branching morphogenesis of an epithelial tube midbrain development activin receptor signaling pathway morphogenesis of an epithelial fold regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 151449 238057 Ensembl ENSG00000143869 ENSMUSG00000037660 UniProt Q7Z4P5 P43029 RefSeq (mRNA) NM_182828 NM_013527 NM_001312876 RefSeq (protein) NP_878248 NP_001299805 NP_038555 Location (UCSC) Chr 2: 20.67 – 20.68 Mb Chr 12: 8.35 – 8.35 Mb PubMed search [3] [4]
Wikidata
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GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.^[5][6]

GDF7 is also known as bone morphogenic protein 12 (BMP-12).^[7]