GDI2

For the chemical compound with formula GdI₂, see Gadolinium diiodide.

Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2 gene.^[5][6]

GDI2
Identifiers
Aliases	GDI2, HEL-S-46e, RABGDIB, GDP dissociation inhibitor 2
External IDs	OMIM: 600767; MGI: 99845; HomoloGene: 37488; GeneCards: GDI2; OMA:GDI2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p15.1 Start 5,765,223 bp[1] End 5,842,132 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A1 Start 3,588,063 bp[2] End 3,617,871 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum mucosa of sigmoid colon corpus epididymis trabecular bone visceral pleura parietal pleura secondary oocyte epithelium of nasopharynx oral cavity Top expressed in saccule otic placode renal corpuscle mandibular prominence maxillary prominence otic vesicle condyle fossa medullary collecting duct internal carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function Rab GDP-dissociation inhibitor activity GTPase activator activity small GTPase binding protein binding GDP-dissociation inhibitor activity RNA binding Cellular component cytoplasm vesicle cytosol membrane focal adhesion extracellular exosome extracellular region secretory granule lumen azurophil granule lumen Golgi apparatus synapse Biological process positive regulation of GTPase activity protein transport regulation of catalytic activity regulation of small GTPase mediated signal transduction vesicle-mediated transport signal transduction small GTPase mediated signal transduction neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2665 14569 Ensembl ENSG00000057608 ENSMUSG00000021218 UniProt P50395 Q5SX91 Q61598 RefSeq (mRNA) NM_001494 NM_001115156 NM_008112 RefSeq (protein) NP_001108628 NP_001485 NP_032138 Location (UCSC) Chr 10: 5.77 – 5.84 Mb Chr 13: 3.59 – 3.62 Mb PubMed search [3] [4]
Wikidata
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GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements.^[6]