GEFT

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.^[5]

ARHGEF25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RGN
Identifiers
Aliases	ARHGEF25, GEFT, p63RhoGEF, Rho guanine nucleotide exchange factor 25
External IDs	OMIM: 610215; MGI: 1277173; HomoloGene: 32691; GeneCards: ARHGEF25; OMA:ARHGEF25 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 57,610,180 bp[1] End 57,617,245 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 74.5 cM Start 127,018,394 bp[2] End 127,025,952 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right coronary artery gastric mucosa body of uterus muscle layer of sigmoid colon popliteal artery tibial arteries left uterine tube myometrium thoracic aorta Top expressed in dentate gyrus of hippocampal formation granule cell hippocampus proper CA3 field primary visual cortex primary motor cortex superior frontal gyrus vas deferens Region I of hippocampus proper umbilical cord lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol plasma membrane myofibril sarcomere membrane Biological process regulation of Rho protein signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115557 52666 Ensembl ENSG00000240771 ENSMUSG00000019467 UniProt Q86VW2 Q9CWR0 RefSeq (mRNA) NM_001111270 NM_133483 NM_182947 NM_001347933 NM_001166413 NM_028027 NM_001358557 NM_001358558 RefSeq (protein) NP_001104740 NP_891992 NP_001334862 NP_001159885 NP_082303 NP_001345486 NP_001345487 Location (UCSC) Chr 12: 57.61 – 57.62 Mb Chr 10: 127.02 – 127.03 Mb PubMed search [3] [4]
Wikidata
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Interactions

GEFT has been shown to interact with RHOA.^[6]