GFRA3

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.^[5][6]

GFRA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GH0
Identifiers
Aliases	GFRA3, GDNFR3, GDNF family receptor alpha 3
External IDs	OMIM: 605710; MGI: 1201403; HomoloGene: 1146; GeneCards: GFRA3; OMA:GFRA3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,252,380 bp[1] End 138,274,621 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 34,822,951 bp[2] End 34,853,440 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia trigeminal ganglion tibial nerve testicle sural nerve gonad muscle layer of sigmoid colon vena cava seminal vesicula mucosa of transverse colon Top expressed in lumbar spinal ganglion trigeminal ganglion superior cervical ganglion external carotid artery embryo urethra female urethra male urethra internal carotid artery carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding axon guidance receptor activity protein binding signaling receptor activity Cellular component membrane anchored component of membrane external side of plasma membrane extrinsic component of membrane plasma membrane cytosol receptor complex Biological process neuron development neuron migration peripheral nervous system development sympathetic nervous system development signal transduction nervous system development MAPK cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2676 14587 Ensembl ENSG00000146013 ENSMUSG00000024366 UniProt O60609 O35118 RefSeq (mRNA) NM_001496 NM_010280 RefSeq (protein) NP_001487 NP_034410 Location (UCSC) Chr 5: 138.25 – 138.27 Mb Chr 18: 34.82 – 34.85 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the artemin ligand.^[6]

In mouse models of osteoarthritis, GFRα3 was upregulated in sensory nerves. Treating arthritic mice with monoclonal antibodies that bind to GFRα3 prevents artemin from binding there and signaling pain. Treated mice were able to use their limbs again two hours post-treatment.^[7]

See also

• GFRα