GFRA4

GDNF family receptor alpha-4 (GFRα4), also known as the persephin receptor, is a protein that in humans is encoded by the GFRA4 gene.^[5]

GFRA4
Identifiers
Aliases	GFRA4, GDNF family receptor alpha 4
External IDs	MGI: 1341873; HomoloGene: 10565; GeneCards: GFRA4; OMA:GFRA4 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,659,248 bp[1] End 3,663,399 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.26 cM Start 130,881,552 bp[2] End 130,885,008 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad periodontal fiber right lobe of thyroid gland prefrontal cortex left lobe of thyroid gland Amygdala hippocampus proper Brodmann area 9 kidney Top expressed in urinary bladder striatum of neuraxis superior frontal gyrus primary visual cortex hippocampus proper dentate gyrus of hippocampal formation granule cell olfactory bulb substantia nigra spermatocyte thyroid gland More reference expression data BioGPS n/a
Gene ontology Molecular function glial cell-derived neurotrophic factor receptor activity signaling receptor activity Cellular component extracellular region membrane anchored component of membrane plasma membrane intracellular anatomical structure extracellular space external side of plasma membrane receptor complex Biological process negative regulation of ossification glial cell-derived neurotrophic factor receptor signaling pathway MAPK cascade axon guidance nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64096 14588 Ensembl ENSG00000125861 ENSMUSG00000027316 UniProt Q9GZZ7 Q9JJT2 RefSeq (mRNA) NM_022139 NM_145762 NM_145763 NM_001136063 NM_001271001 NM_001271002 NM_020014 RefSeq (protein) NP_071422 NP_665705 NP_001129535 NP_001257930 NP_001257931 NP_064398 NP_001394167 NP_001394168 Location (UCSC) Chr 20: 3.66 – 3.66 Mb Chr 2: 130.88 – 130.89 Mb PubMed search [3] [4]
Wikidata
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See also

• GFRα