GINS2

DNA replication complex GINS protein PSF2 is a protein that in humans is encoded by the GINS2 gene.^[5][6][7]

GINS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9X, 2EHO, 2Q9Q
Identifiers
Aliases	GINS2, HSPC037, PSF2, Pfs2, GINS complex subunit 2
External IDs	OMIM: 610609; MGI: 1921019; HomoloGene: 41105; GeneCards: GINS2; OMA:GINS2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 85,676,198 bp[1] End 85,690,073 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 121,305,372 bp[2] End 121,316,043 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ventricular zone embryo ganglionic eminence sperm bone marrow mucosa of transverse colon trabecular bone testicle Top expressed in yolk sac tail of embryo embryo embryo genital tubercle epiblast blastocyst ventricular zone zygote primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 3'-5' DNA helicase activity protein binding Cellular component GINS complex replication fork protection complex nucleus nucleoplasm Biological process DNA replication DNA strand elongation involved in DNA replication double-strand break repair via break-induced replication mitotic DNA replication initiation DNA duplex unwinding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51659 272551 Ensembl ENSG00000131153 ENSMUSG00000031821 UniProt Q9Y248 Q9D600 RefSeq (mRNA) NM_016095 NM_178856 RefSeq (protein) NP_057179 NP_849187 Location (UCSC) Chr 16: 85.68 – 85.69 Mb Chr 8: 121.31 – 121.32 Mb PubMed search [3] [4]
Wikidata
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Interactions

GINS2 has been shown to interact with CHEK2.^[8]