GJA4

Gap junction alpha-4 protein, also known as Connexin-37 or Cx37, is a protein that in humans is encoded by the GJA4 gene.^[5][6][7] This protein, like other Connexin proteins, forms connections between cells known as gap junctions. Connexin 37 can be found in many tissues including the ovary,^[8] heart,^[9] and kidney.^[10]

GJA4
Identifiers
Aliases	GJA4, CX37, gap junction protein alpha 4
External IDs	OMIM: 121012; MGI: 95715; HomoloGene: 1556; GeneCards: GJA4; OMA:GJA4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 34,792,999 bp[1] End 34,795,747 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 61.47 cM Start 127,205,214 bp[2] End 127,207,832 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial arteries apex of heart right lung vena cava left ventricle left coronary artery right lobe of thyroid gland right coronary artery subcutaneous adipose tissue right ventricle Top expressed in primary oocyte morula external carotid artery internal carotid artery secondary oocyte zygote right lung right lung lobe left lung ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane gap junction cell junction plasma membrane integral component of plasma membrane connexin complex membrane Biological process cell communication cell-cell signaling blood vessel development response to pain calcium ion transport cell-cell junction assembly endothelium development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2701 14612 Ensembl ENSG00000187513 ENSMUSG00000050234 UniProt P35212 P28235 RefSeq (mRNA) NM_002060 NM_008120 RefSeq (protein) NP_002051 NP_032146 Location (UCSC) Chr 1: 34.79 – 34.8 Mb Chr 4: 127.21 – 127.21 Mb PubMed search [3] [4]
Wikidata
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