GLRA3

The Glycine receptor subunit alpha-3 is a protein that in humans is encoded by the GLRA3 gene.^[5] The protein encoded by this gene is a subunit of the glycine receptor.^[5]

GLRA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5CFB
Identifiers
Aliases	GLRA3, glycine receptor alpha 3
External IDs	OMIM: 600421; MGI: 95749; HomoloGene: 142; GeneCards: GLRA3; OMA:GLRA3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q34.1 Start 174,636,920 bp[1] End 174,829,247 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B2|8 29.69 cM Start 56,393,495 bp[2] End 56,583,105 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle pancreatic ductal cell prefrontal cortex islet of Langerhans gonad Brodmann area 9 cingulate gyrus anterior cingulate cortex right frontal lobe hypothalamus Top expressed in substantia nigra ventromedial nucleus ventral tegmental area anterior amygdaloid area dorsomedial hypothalamic nucleus superior colliculus paraventricular nucleus of hypothalamus lumbar subsegment of spinal cord lateral hypothalamus utricle More reference expression data BioGPS n/a
Gene ontology Molecular function glycine-gated chloride ion channel activity glycine binding metal ion binding transmitter-gated ion channel activity chloride channel activity extracellular ligand-gated ion channel activity extracellularly glycine-gated chloride channel activity ion channel activity transmembrane signaling receptor activity Cellular component integral component of membrane perikaryon postsynaptic membrane cell projection membrane plasma membrane synapse integral component of plasma membrane chloride channel complex glycine-gated chloride channel complex cell junction dendrite neuron projection Biological process response to amino acid chloride transmembrane transport ion transport synaptic transmission, glycinergic chloride transport neuropeptide signaling pathway protein homooligomerization excitatory postsynaptic potential ion transmembrane transport signal transduction chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8001 110304 Ensembl ENSG00000145451 ENSMUSG00000038257 UniProt O75311 Q91XP5 RefSeq (mRNA) NM_001042543 NM_006529 NM_080438 NM_001368774 RefSeq (protein) NP_001036008 NP_006520 NP_536686 NP_001355703 Location (UCSC) Chr 4: 174.64 – 174.83 Mb Chr 8: 56.39 – 56.58 Mb PubMed search [3] [4]
Wikidata
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