GLRX

Glutaredoxin-1 is a protein that in humans is encoded by the GLRX gene.^[5][6]

GLRX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B4Q, 1JHB, 4RQR
Identifiers
Aliases	GLRX, GRX, GRX1, glutaredoxin
External IDs	OMIM: 600443; MGI: 2135625; HomoloGene: 37566; GeneCards: GLRX; OMA:GLRX - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q15 Start 95,751,319 bp[1] End 95,822,726 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 C1|13 40.95 cM Start 75,987,987 bp[2] End 75,998,273 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa decidua stromal cell of endometrium monocyte skin of thigh mucosa of ileum duodenum oocyte gastrocnemius muscle human kidney Top expressed in granulocyte esophagus primary oocyte jejunum ileum lip duodenum zygote blastocyst epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-disulfide reductase activity electron transfer activity glutathione oxidoreductase activity protein N-terminus binding glutathione disulfide oxidoreductase activity Cellular component cytoplasm cytosol extracellular exosome mitochondrion nucleus Biological process positive regulation of sodium ion transmembrane transporter activity nucleobase-containing small molecule interconversion positive regulation of membrane potential protein deglutathionylation cell redox homeostasis electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2745 93692 Ensembl ENSG00000173221 ENSMUSG00000021591 UniProt P35754 Q9QUH0 RefSeq (mRNA) NM_002064 NM_001118890 NM_001243658 NM_001243659 NM_053108 NM_001360151 RefSeq (protein) NP_001112362 NP_001230587 NP_001230588 NP_002055 NP_444338 NP_001347080 Location (UCSC) Chr 5: 95.75 – 95.82 Mb Chr 13: 75.99 – 76 Mb PubMed search [3] [4]
Wikidata
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Interactions

GLRX has been shown to interact with Wilson disease protein^[7] and ATP7A.^[7]