GLUD2

Glutamate dehydrogenase 2, mitochondrial, also known as GDH 2, is an enzyme that in humans is encoded by the GLUD2 gene.^[3][4][5] This dehydrogenase is one of the family of glutamate dehydrogenases that are ubiquitous in life.

GLUD2
Identifiers
Aliases	GLUD2, GDH2, GLUDP1, glutamate dehydrogenase 2
External IDs	OMIM: 300144; HomoloGene: 115647; GeneCards: GLUD2; OMA:GLUD2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq24 Start 121,047,610 bp[1] End 121,050,094 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis testicle placenta right adrenal gland right adrenal cortex liver right lobe of liver human kidney left adrenal gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function ADP binding oxidoreductase activity GTP binding leucine binding glutamate dehydrogenase [NAD(P)+ activity] glutamate dehydrogenase (NAD+) activity oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Cellular component cytoplasm mitochondrion Biological process cellular amino acid metabolic process glutamate metabolic process glutamate catabolic process glutamate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2747 n/a Ensembl ENSG00000182890 ENSG00000288118 n/a UniProt P49448 n/a RefSeq (mRNA) NM_012084 n/a RefSeq (protein) NP_036216 n/a Location (UCSC) Chr X: 121.05 – 121.05 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

Glutamate dehydrogenase 2 is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate.^[3]