GMDS (gene)

GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene.^[5][6][7]

GMDS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T2A
Identifiers
Aliases	GMDS, GMD, SDR3E1, GDP-mannose 4,6-dehydratase
External IDs	OMIM: 602884; MGI: 1891112; HomoloGene: 75968; GeneCards: GMDS; OMA:GMDS - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.3 Start 1,623,806 bp[1] End 2,245,605 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.2 Start 32,003,562 bp[2] End 32,522,723 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of transverse colon Descending thoracic aorta rectum ascending aorta duodenum minor salivary glands palpebral conjunctiva right coronary artery mucosa of sigmoid colon Top expressed in Paneth cell epithelium of stomach large intestine colon duodenum jejunum left colon ileum rib epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding NADP+ binding lyase activity GDP-mannose 4,6-dehydratase activity identical protein binding Cellular component cytosol extracellular exosome cytoplasm Biological process GDP-mannose metabolic process 'de novo' GDP-L-fucose biosynthetic process Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2762 218138 Ensembl ENSG00000112699 ENSMUSG00000038372 UniProt O60547 Q8K0C9 RefSeq (mRNA) NM_001253846 NM_001500 NM_146041 RefSeq (protein) NP_001240775 NP_001491 NP_666153 Location (UCSC) Chr 6: 1.62 – 2.25 Mb Chr 13: 32 – 32.52 Mb PubMed search [3] [4]
Wikidata
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