GMEB2

Glucocorticoid modulatory element-binding protein 2 is a protein that in humans is encoded by the GMEB2 gene.^[5][6][7]

GMEB2
Identifiers
Aliases	GMEB2, P79PIF, PIF79, GMEB-2, glucocorticoid modulatory element binding protein 2
External IDs	OMIM: 607451; MGI: 2652836; HomoloGene: 8228; GeneCards: GMEB2; OMA:GMEB2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,587,602 bp[1] End 63,627,101 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 180,893,242 bp[2] End 180,929,828 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland buccal mucosa cell thymus mucosa of urinary bladder mucosa of ileum pancreatic ductal cell granulocyte right lobe of thyroid gland tibialis anterior muscle blood Top expressed in granulocyte hand otolith organ utricle cumulus cell blood medial ganglionic eminence neural layer of retina thymus bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding transcription coactivator activity metal ion binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26205 229004 Ensembl ENSG00000101216 ENSMUSG00000038705 UniProt Q9UKD1 P58929 RefSeq (mRNA) NM_012384 NM_198169 RefSeq (protein) NP_036516 NP_937812 Location (UCSC) Chr 20: 63.59 – 63.63 Mb Chr 2: 180.89 – 180.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites.^[7]