GNA11

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene.^[5][6] Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.^[7]

GNA11
Identifiers
Aliases	GNA11, FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2, G protein subunit alpha 11, HG1K
External IDs	OMIM: 139313; MGI: 95766; HomoloGene: 20474; GeneCards: GNA11; OMA:GNA11 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,094,362 bp[1] End 3,123,999 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 81,364,558 bp[2] End 81,381,024 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa pancreatic ductal cell duodenum mucosa of transverse colon secondary oocyte cerebellar vermis parotid gland right hemisphere of cerebellum stromal cell of endometrium Top expressed in crypt of lieberkuhn of small intestine duodenum jejunum ileum intestinal villus migratory enteric neural crest cell epithelium of small intestine left colon Ileal epithelium Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding type 2A serotonin receptor binding GTP binding metal ion binding guanyl nucleotide binding G protein-coupled receptor binding GTPase activity signal transducer activity G-protein beta/gamma-subunit complex binding protein binding Cellular component cytoplasm membrane plasma membrane photoreceptor outer segment lysosomal membrane extracellular exosome heterotrimeric G-protein complex Biological process G protein-coupled acetylcholine receptor signaling pathway skeletal system development regulation of melanocyte differentiation entrainment of circadian clock platelet activation heart development cellular response to pH phospholipase C-activating dopamine receptor signaling pathway phototransduction, visible light developmental pigmentation action potential signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2767 14672 Ensembl ENSG00000088256 ENSMUSG00000034781 UniProt P29992 P21278 RefSeq (mRNA) NM_002067 NM_010301 RefSeq (protein) NP_002058 NP_034431 Location (UCSC) Chr 19: 3.09 – 3.12 Mb Chr 10: 81.36 – 81.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Gq alpha subunit