GNB2

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene.^[4][5]

GNB2
Identifiers
Aliases	GNB2, G protein subunit beta 2, SSS4, SSS4; NEDHYDF, HG2C1
External IDs	OMIM: 139390; MGI: 95784; HomoloGene: 68451; GeneCards: GNB2; OMA:GNB2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,673,567 bp[1] End 100,679,174 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone anterior pituitary granulocyte stromal cell of endometrium skin of leg ganglionic eminence right uterine tube olfactory zone of nasal mucosa skin of abdomen ectocervix n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding calcium channel regulator activity signal transducer activity protein binding GTPase activity GTPase binding Cellular component cytoplasm cell body vesicle membrane focal adhesion myelin sheath plasma membrane lysosomal membrane perinuclear region of cytoplasm extracellular exosome cytosol extracellular space protein-containing complex Biological process G protein-coupled receptor signaling pathway cellular response to glucagon stimulus signal transduction protein folding regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2783 14693 Ensembl ENSG00000172354 n/a UniProt P62879 P62880 RefSeq (mRNA) NM_005273 NM_010312 RefSeq (protein) NP_005264 NP_034442 Location (UCSC) Chr 7: 100.67 – 100.68 Mb n/a PubMed search [2] [3]
Wikidata
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Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes.

This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR.^[5]