GNG2

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.^[5][6]

GNG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KFM, 5HE3, 5HE0, 5HE2, 5HE1
Identifiers
Aliases	GNG2, G protein subunit gamma 2
External IDs	OMIM: 606981; MGI: 102705; HomoloGene: 40715; GeneCards: GNG2; OMA:GNG2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 51,826,195 bp[1] End 51,979,342 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3|14 11.17 cM Start 19,922,627 bp[2] End 20,027,695 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ganglionic eminence left testis right testis bone marrow cells Brodmann area 46 middle temporal gyrus epithelium of colon blood spinal ganglia Top expressed in dentate gyrus of hippocampal formation granule cell ganglionic eminence medial ganglionic eminence dorsomedial hypothalamic nucleus granulocyte paraventricular nucleus of hypothalamus arcuate nucleus subiculum lateral hypothalamus median eminence More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G-protein beta-subunit binding protein binding GTPase activity Cellular component heterotrimeric G-protein complex plasma membrane extracellular exosome membrane G-protein beta/gamma-subunit complex Biological process cellular response to glucagon stimulus cell population proliferation signal transduction cellular response to catecholamine stimulus platelet activation adenylate cyclase-activating dopamine receptor signaling pathway cellular response to prostaglandin E stimulus protein folding Wnt signaling pathway, calcium modulating pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54331 14702 Ensembl ENSG00000186469 ENSMUSG00000043004 UniProt P59768 P63213 RefSeq (mRNA) NM_001243773 NM_001243774 NM_053064 NM_001038637 NM_001285908 NM_001285909 NM_001285910 NM_001285911 NM_010315 RefSeq (protein) NP_001230702 NP_001230703 NP_444292 NP_001033726 NP_001272837 NP_001272838 NP_001272839 NP_001272840 NP_034445 Location (UCSC) Chr 14: 51.83 – 51.98 Mb Chr 14: 19.92 – 20.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

1. The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".