GNG3

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.^[5][6]

GNG3
Identifiers
Aliases	GNG3, G protein subunit gamma 3, HG3D
External IDs	OMIM: 608941; MGI: 102704; HomoloGene: 22575; GeneCards: GNG3; OMA:GNG3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,707,676 bp[1] End 62,709,201 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 5.76 cM Start 8,814,297 bp[2] End 8,816,558 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum dorsolateral prefrontal cortex prefrontal cortex cingulate gyrus anterior cingulate cortex Brodmann area 9 spinal ganglia Amygdala ganglionic eminence Top expressed in perirhinal cortex entorhinal cortex central gray substance of midbrain medial dorsal nucleus CA3 field inferior colliculi subiculum superior colliculus primary motor cortex paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor binding signal transducer activity type 1 angiotensin receptor binding protein binding GTPase activity G-protein beta-subunit binding Cellular component cell body plasma membrane dendrite membrane heterotrimeric G-protein complex postsynaptic density G-protein beta/gamma-subunit complex Biological process positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2785 14704 Ensembl ENSG00000162188 ENSMUSG00000071658 UniProt P63215 P63216 RefSeq (mRNA) NM_012202 NM_010316 RefSeq (protein) NP_036334 NP_034446 Location (UCSC) Chr 11: 62.71 – 62.71 Mb Chr 19: 8.81 – 8.82 Mb PubMed search [3] [4]
Wikidata
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G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM]^[6]