GNL3

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.^[4][5][6] It is found within the nucleolus that binds p53.^[7] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.^[7] It is a marker for many stem cells and cancer cells.^[8]

GNL3
Identifiers
Aliases	GNL3, C77032, E2IG3, NNP47, NS, G protein nucleolar 3
External IDs	OMIM: 608011; MGI: 1353651; HomoloGene: 56670; GeneCards: GNL3; OMA:GNL3 - orthologs
Gene location (Mouse) Chr. Chromosome 14 (mouse)[1] Band 14 B|14 19.09 cM Start 30,734,390 bp[1] End 30,741,109 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon body of pancreas islet of Langerhans minor salivary glands rectum thymus peritoneum skin of abdomen anterior pituitary left uterine tube Top expressed in tail of embryo epiblast genital tubercle embryo morula embryo ovary uterus blastocyst placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding RNA binding GTPase activity mRNA 5'-UTR binding Cellular component membrane nucleus nucleoplasm nucleolus extracellular space nuclear body Biological process positive regulation of protein localization to chromosome, telomeric region positive regulation of telomere maintenance cell population proliferation regulation of cell population proliferation positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of protein sumoylation stem cell division stem cell population maintenance ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26354 30877 Ensembl n/a ENSMUSG00000042354 UniProt Q9BVP2 Q8CI11 RefSeq (mRNA) NM_206826 NM_014366 NM_206825 NM_153547 NM_178846 RefSeq (protein) NP_055181 NP_996561 NP_996562 NP_705775 Location (UCSC) n/a Chr 14: 30.73 – 30.74 Mb PubMed search [2] [3]
Wikidata
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Interactions

GNL3 has been shown to interact with Mdm2^[9] and P53.^[5]