GNPDA2

Glucosamine-6-phosphate deaminase 2 also known as GNPDA2 is an enzyme that in humans is encoded by the GNPDA2 gene.^[5]

GNPDA2
Identifiers
Aliases	GNPDA2, GNP2, SB52, glucosamine-6-phosphate deaminase 2
External IDs	OMIM: 613222; MGI: 1915230; HomoloGene: 12381; GeneCards: GNPDA2; OMA:GNPDA2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p12 Start 44,682,200 bp[1] End 44,726,588 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.1 Start 69,730,451 bp[2] End 69,749,683 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon ventricular zone islet of Langerhans ganglionic eminence smooth muscle tissue cerebellar hemisphere right hemisphere of cerebellum Brodmann area 9 Descending thoracic aorta Top expressed in spermatid olfactory epithelium zygote secondary oocyte lumbar spinal ganglion atrioventricular valve primary oocyte lateral septal nucleus ventromedial nucleus seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding hydrolase activity glucosamine-6-phosphate deaminase activity identical protein binding Cellular component nucleus cytosol cytoplasm Biological process N-acetylglucosamine metabolic process glucosamine catabolic process carbohydrate metabolic process N-acetylglucosamine catabolic process UDP-N-acetylglucosamine biosynthetic process N-acetylneuraminate catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 132789 67980 Ensembl ENSG00000163281 ENSMUSG00000029209 UniProt Q8TDQ7 Q9CRC9 RefSeq (mRNA) NM_001270880 NM_001270881 NM_138335 NM_001038015 NM_027681 NM_001347363 NM_001359239 RefSeq (protein) NP_001257809 NP_001257810 NP_612208 NP_001033104 NP_001334292 NP_001346168 Location (UCSC) Chr 4: 44.68 – 44.73 Mb Chr 5: 69.73 – 69.75 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Variants of the GNPDA2 gene may be associated with obesity.^[6][7][8]