GNRHR2

Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.^[3][4]

GNRHR2
Identifiers
Aliases	GNRHR2, GnRH-II-R, gonadotropin releasing hormone receptor 2 (pseudogene)
External IDs	GeneCards: GNRHR2; OMA:GNRHR2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,919,013 bp[1] End 145,925,341 bp[1]
Orthologs Species Human Mouse Entrez 114814 n/a Ensembl ENSG00000211451 n/a UniProt n a n/a RefSeq (mRNA) NM_057163 NM_206994 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 1: 145.92 – 145.93 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The receptor for gonadotropin-releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in humans, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.^[4]

See also

• Gonadotropin-releasing hormone receptor