GOLGA5

Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene.^[5][6][7][8]

GOLGA5
Identifiers
Aliases	GOLGA5, GOLIM5, RFG5, ret-II, golgin A5, GOLGIN 84
External IDs	OMIM: 606918; MGI: 1351475; HomoloGene: 38009; GeneCards: GOLGA5; OMA:GOLGA5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.12 Start 92,794,305 bp[1] End 92,839,947 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 102,435,394 bp[2] End 102,464,166 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte islet of Langerhans Achilles tendon parotid gland olfactory zone of nasal mucosa rectum skin of hip right lobe of liver body of pancreas corpus epididymis Top expressed in zygote secondary oocyte calvaria parotid gland primary oocyte temporal muscle right ventricle ankle stroma of bone marrow triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity Cellular component cis-Golgi network Golgi cisterna membrane Golgi apparatus transport vesicle Golgi membrane integral component of membrane Biological process Golgi vesicle transport Golgi organization retrograde transport, vesicle recycling within Golgi Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9950 27277 Ensembl ENSG00000066455 ENSMUSG00000021192 UniProt Q8TBA6 Q9QYE6 RefSeq (mRNA) NM_005113 NM_001199004 NM_013747 RefSeq (protein) NP_005104 NP_001185933 NP_038775 Location (UCSC) Chr 14: 92.79 – 92.84 Mb Chr 12: 102.44 – 102.46 Mb PubMed search [3] [4]
Wikidata
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The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins, whose members localize to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5.^[8]

Interactions

GOLGA5 has been shown to interact with RAB1A.^[9][10]