GOPC

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.^[5][6][7]

GOPC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DC2, 2LOB, 4E34, 4E35, 4JOE, 4JOF, 4JOG, 4JOH, 4JOJ, 4JOK, 4JOP, 4JOR, 4K6Y, 4K72, 4K75, 4K76, 4K78, 4NMO, 4NMP, 4NMQ, 4NMR, 4NMS, 4NMT, 4NMV, 4Q6H, 4Q6S
Identifiers
Aliases	GOPC, CAL, FIG, GOPC1, PIST, dJ94G16.2, golgi-associated PDZ and coiled-coil motif containing, golgi associated PDZ and coiled-coil motif containing
External IDs	OMIM: 606845; MGI: 2149946; HomoloGene: 10695; GeneCards: GOPC; OMA:GOPC - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.1 Start 117,560,269 bp[1] End 117,602,542 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B3 Start 52,211,946 bp[2] End 52,258,220 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia pancreatic epithelial cell parietal pleura visceral pleura secondary oocyte germinal epithelium middle temporal gyrus skin of arm tendon of biceps brachii Achilles tendon Top expressed in trigeminal ganglion medullary collecting duct dorsomedial hypothalamic nucleus piriform cortex lumbar spinal ganglion dentate gyrus of hippocampal formation granule cell ascending aorta epithelium of lens right kidney atrioventricular valve More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane transporter binding protein binding frizzled binding protein C-terminus binding GTPase regulator activity protein homodimerization activity Cellular component lysosomal membrane Golgi-associated vesicle membrane trans-Golgi network transport vesicle synapse cell projection cell junction Golgi membrane postsynaptic density postsynaptic membrane dendrite membrane Golgi apparatus cytoplasm plasma membrane protein-containing complex Biological process endoplasmic reticulum to Golgi vesicle-mediated transport protein homooligomerization apical protein localization protein transport Golgi to plasma membrane transport negative regulation of anion channel activity cytoplasmic sequestering of CFTR protein negative regulation of protein localization to cell surface spermatid nucleus differentiation regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57120 94221 Ensembl ENSG00000047932 ENSMUSG00000019861 UniProt Q9HD26 Q8BH60 RefSeq (mRNA) NM_020399 NM_001017408 NM_001199272 NM_053187 RefSeq (protein) NP_001017408 NP_065132 NP_001186201 NP_444417 Location (UCSC) Chr 6: 117.56 – 117.6 Mb Chr 10: 52.21 – 52.26 Mb PubMed search [3] [4]
Wikidata
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PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM]^[7]

Interactions

GOPC has been shown to interact with GRID2,^[8] BECN1,^[8] RHOQ,^[5] ACCN3,^[9] Cystic fibrosis transmembrane conductance regulator^[10][11] and CSPG5.^[12]