GPA33

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.^[5][6][7]

GPA33
Identifiers
Aliases	GPA33, A33, glycoprotein A33
External IDs	OMIM: 602171; MGI: 1891703; HomoloGene: 4245; GeneCards: GPA33; OMA:GPA33 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.1 Start 167,052,836 bp[1] End 167,166,479 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.3|1 73.49 cM Start 165,957,807 bp[2] End 165,994,079 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of transverse colon rectum jejunal mucosa mucosa of sigmoid colon duodenum appendix epithelium of colon granulocyte blood Top expressed in intestinal villus left colon crypt of lieberkuhn of small intestine jejunum basilar part of occipital bone duodenum ileum transitional epithelium of urinary bladder humerus Meckel's cartilage More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 10223 59290 Ensembl ENSG00000143167 ENSMUSG00000000544 UniProt Q99795 Q9JKA5 RefSeq (mRNA) NM_005814 NM_021610 NM_001360925 NM_001360926 RefSeq (protein) NP_005805 NP_067623 NP_001347854 NP_001347855 Location (UCSC) Chr 1: 167.05 – 167.17 Mb Chr 1: 165.96 – 165.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.^[7]