GPIHBP1

Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPI-HBP1) also known as high density lipoprotein-binding protein 1 is a protein that in humans is encoded by the GPIHBP1 gene.^[5]

GPIHBP1
Identifiers
Aliases	GPIHBP1, GPI-HBP1, HYPL1D, glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
External IDs	OMIM: 612757; MGI: 1915703; HomoloGene: 18651; GeneCards: GPIHBP1; OMA:GPIHBP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 143,213,218 bp[1] End 143,217,170 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 75,468,477 bp[2] End 75,471,330 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart C1 segment abdominal fat subcutaneous adipose tissue substantia nigra left ventricle sural nerve upper lobe of left lung right lung muscle of leg Top expressed in right lung right lung lobe interventricular septum brown adipose tissue myocardium of ventricle muscle of thigh soleus muscle thoracic diaphragm tibialis anterior muscle digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function lipid binding protein transmembrane transporter activity lipase binding chylomicron binding lipoprotein particle binding protein binding Cellular component membrane intracellular anatomical structure basolateral plasma membrane apical plasma membrane anchored component of external side of plasma membrane high-density lipoprotein particle anchored component of membrane extracellular region plasma membrane external side of plasma membrane Biological process protein transmembrane transport response to heparin regulation of lipoprotein lipase activity intracellular protein transport protein import protein localization to cell surface cholesterol homeostasis transcytosis protein stabilization positive regulation of lipoprotein lipase activity triglyceride homeostasis positive regulation of chylomicron remnant clearance retinoid metabolic process chylomicron remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338328 68453 Ensembl ENSG00000277494 ENSMUSG00000022579 UniProt Q8IV16 Q9D1N2 RefSeq (mRNA) NM_178172 NM_001301772 NM_026730 NM_001347039 NM_001361294 RefSeq (protein) NP_001288701 NP_835466 NP_001333968 NP_081006 NP_001348223 Location (UCSC) Chr 8: 143.21 – 143.22 Mb Chr 15: 75.47 – 75.47 Mb PubMed search [3] [4]
Wikidata
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Function

Dietary fats are packaged by intestine into triglyceride-rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL) along the luminal surface of capillaries, mainly in heart, skeletal muscle, and adipose tissue. GPIHBP1 is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons.^[5][6]