GPR101

Probable G-protein coupled receptor 101 is a protein that is encoded by the GPR101 gene in humans.^[5][6]

GPR101
Identifiers
Aliases	GPR101, GPCR6, PAGH2, G protein-coupled receptor 101, PITA2
External IDs	OMIM: 300393; MGI: 2685211; HomoloGene: 14273; GeneCards: GPR101; OMA:GPR101 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 137,023,929 bp[1] End 137,033,995 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A6 Start 56,542,028 bp[2] End 56,549,117 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus hypothalamus putamen cerebellum cerebellar cortex cerebellar hemisphere spinal cord temporal lobe C1 segment Top expressed in arcuate nucleus lumbar subsegment of spinal cord paraventricular nucleus of hypothalamus subiculum median eminence dorsomedial hypothalamic nucleus anterior amygdaloid area ventromedial nucleus nucleus accumbens nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity adrenergic receptor activity Cellular component integral component of membrane receptor complex plasma membrane integral component of plasma membrane membrane intracellular anatomical structure Biological process adenylate cyclase-activating adrenergic receptor signaling pathway cell-cell signaling G protein-coupled receptor signaling pathway signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83550 245424 Ensembl ENSG00000165370 ENSMUSG00000036357 UniProt Q96P66 Q80T62 RefSeq (mRNA) NM_054021 NM_001033360 RefSeq (protein) NP_473362 NP_001028532 Location (UCSC) Chr X: 137.02 – 137.03 Mb Chr X: 56.54 – 56.55 Mb PubMed search [3] [4]
Wikidata
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G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.^[6]

Clinical significance

A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.^[7]