Top Qs
Timeline
Chat
Perspective
GPR139
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Remove ads
G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene.[5][6] Research has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone.[7][8]
In 2025, GPR139 was identified as a novel opioid receptor, specifically of dynorphins.[9]
Remove ads
Ligands
Agonists
- Zelatriazin (TAK-41), (NBI-1065846) a potent, and GPR139 receptor selective agonist [10] which was in clinical trials to gauge the efficacy for treating psychiatric conditions such as major depressive disorder and the negative symptoms of schizophrenia, but was later dropped from development.
Antagonists
References
Further reading
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads