GPR151

G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene.^[5][6] It is weakly activated by galanin, but its endogenous ligand remains unknown. Studies have suggested GPR151 may play a role in several clinically significant processes such as inflammation, pain perception and reward-seeking behavior as well as hepatic glucose production, but further research into its function has been limited so far by a lack of selective agonists and antagonists for this receptor, with most research to date using knockout mice.^{[7][8][9][10][11]}

GPR151
Identifiers
Aliases	GPR151, GALR4, GALRL, GPCR, PGR7, G protein-coupled receptor 151, GPCR-2037
External IDs	OMIM: 618487; MGI: 2441887; HomoloGene: 18754; GeneCards: GPR151; OMA:GPR151 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 146,513,144 bp[1] End 146,516,190 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 42,710,946 bp[2] End 42,712,717 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex C1 segment Brodmann area 9 superior frontal gyrus primary visual cortex ganglionic eminence anterior cingulate cortex substantia nigra right frontal lobe putamen Top expressed in habenula lumbar spinal ganglion epithelium of small intestine paraventricular nucleus of thalamus embryo blastocyst lateral habenular nucleus gastrula central medial nucleus jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 134391 240239 Ensembl ENSG00000173250 ENSMUSG00000042816 UniProt Q8TDV0 Q7TSN6 RefSeq (mRNA) NM_194251 NM_181543 RefSeq (protein) NP_919227 NP_853521 Location (UCSC) Chr 5: 146.51 – 146.52 Mb Chr 18: 42.71 – 42.71 Mb PubMed search [3] [4]
Wikidata
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