GPR160

Probable G-protein coupled receptor 160 is a protein that in humans is encoded by the GPR160 gene.^[5][6] It has been shown to be important in embryonic stem cell development, is involved in the perception of neuropathic pain, and is present in elevated levels in some cancers.^{[7][8][9][10]} GPR160 has been suggested as the receptor for Cocaine- and amphetamine-regulated transcript, also known as CART.^{[11][12][13][14]} However other research has since shown that it does not appear CART binds to GPR160 directly.^[15][16] This suggests that an as yet unidentified target for CART may modulate GPR160 mediated responses indirectly under certain conditions, but without directly binding to the GPR160 receptor.

GPR160
Identifiers
Aliases	GPR160, GPCR1, GPCR150, G protein-coupled receptor 160
External IDs	MGI: 1919112; HomoloGene: 8659; GeneCards: GPR160; OMA:GPR160 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 170,037,995 bp[1] End 170,085,392 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 30,910,099 bp[2] End 30,951,341 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of sigmoid colon rectum corpus epididymis duodenum bone marrow jejunal mucosa bone marrow cell mucosa of transverse colon trabecular bone Top expressed in spermatocyte spermatid seminiferous tubule lens jejunum epithelium of lens right kidney granulocyte duodenum skin of abdomen More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane receptor complex membrane plasma membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26996 71862 Ensembl ENSG00000173890 ENSMUSG00000037661 UniProt Q9UJ42 Q3U3F9 RefSeq (mRNA) NM_014373 NM_001134385 NM_001134386 NM_001286994 NM_001286995 NM_001286996 NM_027965 NM_001357144 RefSeq (protein) NP_055188 NP_001127857 NP_001127858 NP_001273923 NP_001273924 NP_001273925 NP_082241 NP_001344073 Location (UCSC) Chr 3: 170.04 – 170.09 Mb Chr 3: 30.91 – 30.95 Mb PubMed search [3] [4]
Wikidata
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