GPR161

G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene.^[5][6] It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation.^{[7][8][9][10]}

GPR161
Identifiers
Aliases	GPR161, RE2, G protein-coupled receptor 161
External IDs	OMIM: 612250; MGI: 2685054; HomoloGene: 17824; GeneCards: GPR161; OMA:GPR161 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 168,079,542 bp[1] End 168,137,667 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.2|1 72.64 cM Start 165,123,358 bp[2] End 165,154,314 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence myometrium buccal mucosa cell ventricular zone tail of epididymis body of uterus pars reticulata stromal cell of endometrium spinal ganglia pars compacta Top expressed in subiculum otic vesicle Region I of hippocampus proper ganglionic eminence hand lumbar spinal ganglion morula medial ganglionic eminence hippocampus proper ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity Cellular component plasma membrane cell projection membrane ciliary membrane integral component of membrane endocytic vesicle membrane cilium recycling endosome Biological process multicellular organism development signal transduction G protein-coupled receptor signaling pathway negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23432 240888 Ensembl ENSG00000143147 ENSMUSG00000040836 UniProt Q8N6U8 B2RPY5 RefSeq (mRNA) NM_001267609 NM_001267610 NM_001267611 NM_001267612 NM_001267613 NM_001267614 NM_007369 NM_153832 NM_001349632 NM_001349633 NM_001349634 NM_001349635 NM_001375883 NM_001375884 NM_001375885 NM_001381909 NM_001081126 NM_001310429 NM_001310430 RefSeq (protein) NP_001254538 NP_001254539 NP_001254540 NP_001254541 NP_001254542 NP_001254543 NP_722561 NP_001336561 NP_001336562 NP_001336563 NP_001336564 NP_001362812 NP_001362813 NP_001362814 NP_001368838 NP_001074595 NP_001297358 NP_001297359 Location (UCSC) Chr 1: 168.08 – 168.14 Mb Chr 1: 165.12 – 165.15 Mb PubMed search [3] [4]
Wikidata
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