GPR171

G-protein coupled receptor 171 is a protein that in humans is encoded by the GPR171 gene.^[5][6] It has been recently deorphanised, with its endogenous agonist being a neuropeptide BigLEN which is a cleavage product of proSAAS. GPR174 has been found to be involved in processes such as pain, anxiety, and appetite regulation, as well as immune system function, and GPR174 agonists may represent a potential target for novel analgesic drugs. Interestingly it seems to show sex-selective signalling, with effects seen in male mice often absent in female mice.^{[7][8][9][10][11][12][13][14][15][16]}

GPR171
Identifiers
Aliases	GPR171, H963, G protein-coupled receptor 171
External IDs	MGI: 2442043; HomoloGene: 36330; GeneCards: GPR171; OMA:GPR171 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 151,197,832 bp[1] End 151,203,216 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 D Start 59,003,869 bp[2] End 59,009,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle buccal mucosa cell appendix blood lymph node granulocyte spleen superficial temporal artery amniotic fluid gallbladder Top expressed in mesenteric lymph nodes blood spleen thymus morula subcutaneous adipose tissue embryo embryo blastocyst bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway negative regulation of myeloid cell differentiation signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29909 229323 Ensembl ENSG00000174946 ENSMUSG00000050075 UniProt O14626 Q8BG55 RefSeq (mRNA) NM_013308 NM_173398 RefSeq (protein) NP_037440 NP_775574 Location (UCSC) Chr 3: 151.2 – 151.2 Mb Chr 3: 59 – 59.01 Mb PubMed search [3] [4]
Wikidata
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Ligands

Agonists

• BigLEN
• MS15203