GPR182

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.^[5]

GPR182
Identifiers
Aliases	GPR182, 7TMR, ADMR, AM-R, AMR, G10D, gamrh, hrhAMR, G protein-coupled receptor 182, L1-R
External IDs	OMIM: 605307; MGI: 109545; HomoloGene: 5255; GeneCards: GPR182; OMA:GPR182 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,994,492 bp[1] End 56,998,447 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 75.07 cM Start 127,583,145 bp[2] End 127,587,601 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle spleen sperm tendon of biceps brachii left adrenal cortex right adrenal cortex tibialis anterior muscle liver right testis left testis Top expressed in yolk sac atrium mesenteric lymph nodes right lung liver left lobe of liver right lung lobe endocardial cushion left lung lobe embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component plasma membrane membrane intracellular anatomical structure integral component of membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway intracellular signal transduction signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11318 11536 Ensembl ENSG00000166856 ENSMUSG00000058396 UniProt O15218 P43142 RefSeq (mRNA) NM_007264 NM_007412 RefSeq (protein) NP_009195 NP_031438 Location (UCSC) Chr 12: 56.99 – 57 Mb Chr 10: 127.58 – 127.59 Mb PubMed search [3] [4]
Wikidata
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When this gene was first cloned, it was proposed to encode an adrenomedullin receptor.^[6] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).^[7]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.^[8]