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GPRC5D

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

GPRC5D
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G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.[5] GPRC5D is a class C orphan G protein-coupled receptor predominantly expressed in multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.[6][7][8]

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Structure

Structural analysis of the complex between GPRC5D and talquetamab, a bispecific antibody for the treatment of multiple myeloma, has revealed that GPRC5D exists as a dimer. GPRC5D forms a symmetric dimer via TM4 and TM4/TM5 interactions. The study further demonstrated that only one talquetamab molecule can bind to the dimeric form of GPRC5D. Talquetamab Fab recognizes ECLs and TM3/5/7 of one GPRC5D protomer via six CDRs. [9]

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GPRC5D complexed with Talquetamab Fab (PDB: 9IMA)
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Function

The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined.[5]

See also

References

Further reading

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