GPS1

The COP9 signalosome complex subunit 1 is a protein encoded by the GPS1 gene.^[5][6]

GPS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4WSN
Identifiers
Aliases	GPS1, COPS1, CSN1, SGN1, G protein pathway suppressor 1
External IDs	OMIM: 601934; MGI: 2384801; HomoloGene: 3046; GeneCards: GPS1; OMA:GPS1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,050,691 bp[1] End 82,057,470 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 120,675,098 bp[2] End 120,679,928 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh right hemisphere of cerebellum gastrocnemius muscle right frontal lobe anterior pituitary right testis left testis ganglionic eminence right lobe of liver Top expressed in spermatocyte lens Mesencephalon neural tube rhombencephalon adrenal gland dentate gyrus of hippocampal formation granule cell olfactory bulb ventricular zone striatum of neuraxis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase inhibitor activity protein binding Cellular component cytoplasm COP9 signalosome nucleus nucleoplasm cytosol Biological process JNK cascade transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA damage recognition negative regulation of GTPase activity protein deneddylation post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2873 209318 Ensembl ENSG00000169727 ENSMUSG00000025156 UniProt Q13098 Q99LD4 RefSeq (mRNA) NM_004127 NM_212492 NM_001321089 NM_001321090 NM_001321091 NM_001321092 NM_001321093 NM_001330539 NM_001330541 NM_001177874 NM_145370 NM_001346709 NM_001363440 RefSeq (protein) NP_001308018 NP_001308019 NP_001308020 NP_001308021 NP_001308022 NP_001317468 NP_001317470 NP_004118 NP_997657 n/a Location (UCSC) Chr 17: 82.05 – 82.06 Mb Chr 11: 120.68 – 120.68 Mb PubMed search [3] [4]
Wikidata
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This gene is known to inhibit G-protein and mitogen-activated signal transduction in mammalian cells. The protein encoded by this gene shares significant similarity with Arabidopsis FUS6, a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.^[6]