GPS2 (gene)

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.^[5][6]

GPS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L5G
Identifiers
Aliases	GPS2, AMF-1, G protein pathway suppressor 2
External IDs	OMIM: 601935; MGI: 1891751; HomoloGene: 49599; GeneCards: GPS2; OMA:GPS2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,311,324 bp[1] End 7,315,564 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 69,804,714 bp[2] End 69,807,417 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sural nerve muscle of thigh gastrocnemius muscle pituitary gland anterior pituitary granulocyte apex of heart right lobe of thyroid gland Top expressed in neural layer of retina granulocyte muscle of thigh tail of embryo genital tubercle lip seminiferous tubule yolk sac ventricular zone morula More reference expression data BioGPS n/a
Gene ontology Molecular function GTPase inhibitor activity protein binding cyclin binding transcription coactivator activity transcription corepressor activity Cellular component nucleoplasm nucleus cytoplasm mitochondrion transcription repressor complex cytosol Biological process JNK cascade negative regulation of GTPase activity negative regulation of fat cell differentiation negative regulation of transcription by RNA polymerase II negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of lipid metabolic process B cell differentiation negative regulation of toll-like receptor signaling pathway positive regulation of peroxisome proliferator activated receptor signaling pathway regulation of fat cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of JNK cascade negative regulation of inflammatory response negative regulation of B cell receptor signaling pathway response to mitochondrial depolarisation negative regulation of protein K63-linked ubiquitination transcription, DNA-templated regulation of transcription, DNA-templated viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2874 56310 Ensembl ENSG00000132522 ENSMUSG00000023170 UniProt Q13227 Q921N8 RefSeq (mRNA) NM_004489 NM_019726 NM_001357906 RefSeq (protein) NP_004480 NP_001344835 NP_062700 Location (UCSC) Chr 17: 7.31 – 7.32 Mb Chr 11: 69.8 – 69.81 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.^[6]

Interactions

GPS2 (gene) has been shown to interact with:

• C21orf7,^[7]
• Cyclin A1,^[8]
• EP300,^[9]
• HDAC3,^[10]
• NCOR1,^[10][11][12]
• P53,^[13] and
• TBL1X.^[10]