GPSM1

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.^[5][6][7]

GPSM1
Identifiers
Aliases	GPSM1, AGS3, G-protein signaling modulator 1, G protein signaling modulator 1
External IDs	OMIM: 609491; MGI: 1915089; HomoloGene: 16987; GeneCards: GPSM1; OMA:GPSM1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 136,327,476 bp[1] End 136,359,605 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 26,205,527 bp[2] End 26,238,249 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia cardiac muscle tissue of right atrium right hemisphere of cerebellum retinal pigment epithelium apex of heart myocardium of left ventricle ganglionic eminence cerebellar vermis sural nerve right auricle of heart Top expressed in Rostral migratory stream neural layer of retina saccule barrel cortex cerebellar cortex olfactory bulb atrioventricular valve fossa otic placode substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase regulator activity GDP-dissociation inhibitor activity Cellular component cytoplasm cytosol Golgi apparatus endoplasmic reticulum membrane Golgi membrane endoplasmic reticulum membrane plasma membrane cell cortex protein-containing complex Biological process multicellular organism development cell differentiation nervous system development positive regulation of macroautophagy negative regulation of GTPase activity negative regulation of guanyl-nucleotide exchange factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26086 67839 Ensembl ENSG00000160360 ENSMUSG00000026930 UniProt Q86YR5 Q6IR34 RefSeq (mRNA) NM_001145638 NM_001145639 NM_001200003 NM_015597 NM_001199146 NM_001199147 NM_153410 NM_001355574 NM_001355575 NM_001355576 RefSeq (protein) NP_001139110 NP_001139111 NP_001186932 NP_056412 NP_001186075 NP_001186076 NP_700459 NP_001342503 NP_001342504 NP_001342505 Location (UCSC) Chr 9: 136.33 – 136.36 Mb Chr 2: 26.21 – 26.24 Mb PubMed search [3] [4]
Wikidata
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G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM]^[7]