GPSM2

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.^[5][6][7]

GPSM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SF4, 4WNE, 4WNF, 4WNG, 5A6C
Identifiers
Aliases	GPSM2, CMCS, DFNB82, LGN, PINS, G-protein signaling modulator 2, G protein signaling modulator 2
External IDs	OMIM: 609245; MGI: 1923373; HomoloGene: 56584; GeneCards: GPSM2; OMA:GPSM2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 108,875,350 bp[1] End 108,934,545 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 108,585,954 bp[2] End 108,629,625 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia buccal mucosa cell amniotic fluid tendon of biceps brachii ventricular zone endothelial cell corpus callosum Achilles tendon internal globus pallidus inferior ganglion of vagus nerve Top expressed in neural layer of retina retinal pigment epithelium genital tubercle ventricular zone tail of embryo hair follicle Paneth cell photoreceptor layer of retina tunica media of zone of aorta condyle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G-protein alpha-subunit binding nucleotide binding protein binding GTPase regulator activity identical protein binding GDP-dissociation inhibitor activity dynein complex binding protein C-terminus binding protein domain specific binding protein self-association Cellular component mitotic spindle pole spindle pole cytoskeleton cytosol cytoplasm cell cortex region cell cortex lateral cell cortex plasma membrane membrane lateral plasma membrane centrosome protein-containing complex Biological process mitotic spindle organization G protein-coupled receptor signaling pathway maintenance of centrosome location regulation of catalytic activity Ran protein signal transduction regulation of mitotic spindle organization positive regulation of protein localization to cell cortex positive regulation of spindle assembly cell cycle cell division establishment of mitotic spindle orientation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29899 76123 Ensembl ENSG00000121957 ENSMUSG00000027883 UniProt P81274 Q8VDU0 RefSeq (mRNA) NM_013296 NM_001321038 NM_001321039 NM_029522 RefSeq (protein) NP_001307967 NP_001307968 NP_037428 NP_037428.3 NP_001307967.1 NP_001307968.1 NP_083798 Location (UCSC) Chr 1: 108.88 – 108.93 Mb Chr 3: 108.59 – 108.63 Mb PubMed search [3] [4]
Wikidata
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Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM]^[7]

Interactions

GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1^[8] and GNAI2.^[6][9]