GR-127935

GR-127935 is a drug which acts as a selective antagonist at the serotonin receptors 5-HT_1B and 5-HT_1D.^[1] It has little effect when given by itself but blocks the antiaggressive effect of 5-HT_1B agonists,^[2] and alters release of serotonin in the brain,^[3] as well as reducing drug-seeking behaviour in cocaine addicted rats.^[4]

GR-127935

Clinical data
ATC code	none
Identifiers
IUPAC name N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1-1'-biphenyl-4-carboxamide
CAS Number	148672-13-3 Y
PubChem CID	107780
IUPHAR/BPS	14
ChemSpider	96935
UNII	2LLH6CEB40
ChEBI	CHEBI:64114
ChEMBL	ChEMBL15928 N
CompTox Dashboard (EPA)	DTXSID90164044
Chemical and physical data
Formula	C29H31N5O3
Molar mass	497.599 g·mol−1
3D model (JSmol)	Interactive image
SMILES n5oc(C)nc5-c(cc2C)ccc2-c(cc3)ccc3C(=O)Nc(ccc1OC)cc1N4CCN(C)CC4
InChI InChI=1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,31,35) Key:YDBCEBYHYKAFRX-UHFFFAOYSA-N
NY (what is this?)  (verify)

See also

• Elzasonan