GRAMD4

GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.^[5][6]

GRAMD4
Identifiers
Aliases	GRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4
External IDs	OMIM: 613691; MGI: 2676308; HomoloGene: 18199; GeneCards: GRAMD4; OMA:GRAMD4 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 46,576,012 bp[1] End 46,679,790 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E2 Start 85,941,896 bp[2] End 86,021,835 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right lobe of liver apex of heart sural nerve ventricular zone monocyte ganglionic eminence left ventricle right auricle skin of abdomen Top expressed in interventricular septum pyloric antrum epithelium of stomach trigeminal ganglion ventricular zone mesenteric lymph nodes ganglionic eminence superior cervical ganglion Rostral migratory stream mucous cell of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component mitochondrial membranes integral component of membrane membrane mitochondrion endoplasmic reticulum endoplasmic reticulum membrane Biological process apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of toll-like receptor 9 signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23151 223752 Ensembl ENSG00000075240 ENSMUSG00000035900 UniProt Q6IC98 Q8CB44 RefSeq (mRNA) NM_015124 NM_001366660 NM_001205353 NM_172611 NM_001379572 RefSeq (protein) NP_055939 NP_001353589 NP_001192282 NP_766199 NP_001366501 Location (UCSC) Chr 22: 46.58 – 46.68 Mb Chr 15: 85.94 – 86.02 Mb PubMed search [3] [4]
Wikidata
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Function

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.^[7]