GRAM domain-containing 2B

GRAM domain-containing 2B protein (GRAMD2B; formerly GRAMD3), also known as NS3TP2 and HCV NS3-transactivated protein 2 is a protein encoded by the GRAMD2B gene.^[5][6]

GRAMD2B
Identifiers
Aliases	GRAMD2B, NS3TP2, GRAMD3, GRAM domain containing 3, GRAM domain containing 2B
External IDs	MGI: 1914815; HomoloGene: 32570; GeneCards: GRAMD2B; OMA:GRAMD2B - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q23.2 Start 126,360,132 bp[1] End 126,496,494 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D3 Start 56,533,409 bp[2] End 56,636,864 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon internal globus pallidus corpus callosum external globus pallidus bronchial epithelial cell decidua dorsal motor nucleus of vagus nerve jejunal mucosa Epithelium of choroid plexus caudate nucleus Top expressed in mucous cell of stomach jejunum islet of Langerhans pyloric antrum duodenum epithelium of stomach parotid gland external carotid artery internal carotid artery left lobe of liver More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 65983 107022 Ensembl ENSG00000155324 ENSMUSG00000001700 UniProt Q96HH9 Q6PEM6 RefSeq (mRNA) NM_001146319 NM_001146320 NM_001146321 NM_001146322 NM_023927 NM_001349541 NM_001349542 NM_001349543 NM_001349544 NM_026240 NM_001360917 RefSeq (protein) NP_001139791 NP_001139792 NP_001139793 NP_001139794 NP_076416 NP_001336470 NP_001336471 NP_001336472 NP_001336473 NP_080516 NP_001347846 Location (UCSC) Chr 5: 126.36 – 126.5 Mb Chr 18: 56.53 – 56.64 Mb PubMed search [3] [4]
Wikidata
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GRAMD2B has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2A. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.^[7]

GRAMD2B consists of a GRAM domain and a transmembrane domain anchoring it to the endoplasmic reticulum.^[8][7] Similar to GRAMD2A, GRAMD2B lacks the VASt domain found in LAM and GRAMD1 proteins. Its function has not yet been defined, but is likely similar to that of GRAMD2A.